2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W134007S1
    Hexadecanoate-13C16 potassium 1458714-74-3 98.40%
    Hexadecanoate-13C16 (potassium) is the 13C-labeled Hexadecanoate sodium. Hexadecanoate potassium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Hexadecanoate-13C16 potassium
  • HY-10627
    GW3965 405911-09-3 98%
    GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively.
    GW3965
  • HY-12767
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol 142227-49-4 98.59%
    4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker.
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
  • HY-13063
    Sodium formononetin-3'-sulfonate 949021-68-5 99.79%
    Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol.
    Sodium formononetin-3'-sulfonate
  • HY-13289
    Nepicastat 173997-05-2 98%
    Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB).
    Nepicastat
  • HY-15553
    Mibefradil 116644-53-2 98%
    Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.
    Mibefradil
  • HY-15718
    Istaroxime 203737-93-3 98%
    Istaroxime (PST2744) is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.
    Istaroxime
  • HY-17458
    Azilsartan medoxomil monopotassium 863031-24-7 98.00%
    Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.
    Azilsartan medoxomil monopotassium
  • HY-17567
    Heparin 9005-49-6 98%
    Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.
    Heparin
  • HY-19102
    NSP-805 125068-54-4 ≥99.0%
    NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.
    NSP-805
  • HY-A0018
    Palonosetron 135729-61-2 98%
    Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
    Palonosetron
  • HY-A0066
    Tolazoline 59-98-3 99.99%
    Tolazoline (Imidaline) is an α-adrenergic receptor antagonist. Tolazoline inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research.
    Tolazoline
  • HY-B0165
    Pravastatin 81093-37-0 98%
    Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
    Pravastatin
  • HY-B0917
    Bromindione 1146-98-1
    Bromindione is a potent and long-acting, Inandione-derived, oral anticoagulant compound.
    Bromindione
  • HY-B1088
    Clopidol 2971-90-6 99.77%
    Clopidol (WR-61112) is an anticoccidial agent which is used as feed additive to control coccidiosis in chickens. Clopidol inhibits the sporulation of Eimeria tenella oocysts.
    Clopidol
  • HY-B1304
    (-)-Sparteine sulfate pentahydrate 6160-12-9 98%
    (-)-Sparteine sulfate pentahydrate ((-)-Lupinidine sulfate pentahydrate) is a class 1a antiarrhythmic agent and a sodium channel blocker.
    (-)-Sparteine sulfate pentahydrate
  • HY-B1308
    Adrenalone hydrochloride 62-13-5 99.88%
    Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM.
    Adrenalone hydrochloride
  • HY-Z7721
    (Rac)-Beraprost sodium 88475-69-8 98%
    (Rac)-Beraprost ((Rac)-ML 1129) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis.
    (Rac)-Beraprost sodium
  • HY-101693
    Senazodan 98326-32-0 98%
    Senazodan (MCI 154) is a Ca2+ sensitiser, and also shows inhibition effect on PDE III.
    Senazodan
  • HY-101717
    Indanidine 85392-79-6 99.89%
    Indanidine is an alpha-adrenergic agonist.
    Indanidine
Cat. No. Product Name / Synonyms Application Reactivity